11 hydroxysteroid dehydrogenase type 2

11β-Hydroxysteroid dehydrogenase (HSD-11β or 11β-HSD) enzymes catalyze the conversion of inert 11 keto-products to active cortisol, or vice versa, thus regulating the access of glucocorticoids to the steroid receptors.. The human genome encodes two distinct HSD-11β isozymes (HSD-11β Type 1 and HSD-11β Type 2) on distinct genes.The dehydrogenase activity of a HSD-11β converts a 11beta …

Corticosteroid 11-β-dehydrogenase isozyme 2 is an NAD +-dependent enzyme expressed in aldosterone-selective epithelial tissues such as the kidney, colon, salivary and sweat glands. HSD211B2 expression is also found in the brainstem in a small, aldosterone-sensitive subset of neurons located in the nucleus of the solitary tract referred to as HSD2 neurons .

steroid dehydrogenase type 2. 11 f3-hydroxysteroid dehydrogenase (1113-HSD) catalyzes the oxidation of cortisol and corticosterone to cortisone and il-dehydrocorticosterone, respectively. NAD-dependent I 1f3-HSD is expressed at high levels in the distal nephron and contributes to miner-alocorticoid specificity in that region. The present studies determined whether N-glycosylation is necessary …

11-β hydroxysteroid dehydrogenase type 2 (HSD2) oxidizes the biologically active glucocorticoid (GC), cortisol, to inactive cortisone. We characterized HSD2 gene expression and activity in human…

The expression of 11 beta-hydroxysteroid dehydrogenase type 2 is induced during trophoblast differentiation: effects of hypoxia. An increase in the expression of 11 beta-HSD2 may result in faster glucocorticoid breakdown in lung cells in patients with acute respiratory distress syndrome (ARDS).

In mineralocorticoid target organs the enzyme 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) inactivates 11-hydroxy steroids, to their inactive keto-forms, thus protecting the nonselective MR from activation by glucocorticoids.

Mineralocorticoid receptors are protected from cortisol by the enzyme 11-hydroxysteroid dehydrogenase type 2, which inactivates cortisol to inert cortisone. (B) Mechanisms of mineralocorticoid action of carbenoxolone.